Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview | Mus musculus |
Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme inhibition is a possible tool in cancer therapy both in prophylactic and therapeutic treatment, e.g. by targeting BRCA2 tumors with PARP inhibitors, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, cells isolated from these mice show an increased level of homologous recombination | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Mus musculus | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | mechanism and physiological function, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | role for PARP-1 in DNA double-strand break repair, the enzyme is not required for homologous recombination itself, it regulates the process through its involvement in the repair of DNA single-strand breaks, PARP-1 binds to DNA breaks to facilitate DNA repair, but the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertile and do not develop early onset tumors, DNA binding and auto-modification of PARP-1 attracts the DNA repair proteins | Mus musculus | ? | - |
? | |
additional information | PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks, DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview | Mus musculus | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Mus musculus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PARP-1 protein has an N-terminal DNA binding domain containing two large zinc fingers that bind to both DNA single-strand breaks and DNA double-strand breaks | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PARP-1 | - |
Mus musculus |
poly(ADP-ribose) polymerase | - |
Mus musculus |